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This is a concern that applies to all significant weight loss interventions, not just tirzepatide, but it becomes more relevant as the magnitude of weight loss increases

Tirzepatide suppresses this compensatory ghrelin increase through central nervous system effects, breaking the typical hunger rebound cycle

[PubMed abstract] Zhou Y, Wang A, Yeung LF, Qi YP, Pfeiffer CM, et al

It is involved in the synthesis of thymidine from deoxyuridine, promotion of deposited folate utilisation and metabolism of nucleic acid