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ICIE offers a robust, synergistic platform that combines cryosurgery, controlled drug and gene delivery, and immune regulation to address the shortcomings of traditional cancer treatments, presenting a viable avenue for the treatment of aggressive and metastatic malignancies (Fig

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Previous studies have shown that a reduced nucleotide pool and nucleotide imbalances favor DNA damage [44]

However, some studies show that ASNS levels may not impact the sensitivity of ALL to asparaginase treatments in all cases [98]

(6) can be changed to where Ve denotes the volume of the hypothetical effect compartment, Vd the volume of the central compartment, and Ce and C1 drug concentrations in the respective compartments

The upregulation was most intense in rats that developed a progressive form of epilepsy with five to ten seizures per day