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However, despite some success with agents like colchicine, the general class of broad anti-inflammatories often lacks specificity for the precise inflammatory pathways driving MIRI, leading to a poor risk-benefit profile and inconsistent efficacy in clinical trials for this acute setting

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A Nuanced Interpretation of the Data The absence of evidence is not evidence of absence, but in this case, the volume of available data across multiple populations, decades, and dosing regimens is substantial