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When studies reported multiple brain regions or several blood components (plasma, serum, blood cells), each region or component was extracted as a sub-study

Following the development of numerous drugs targeting previously identified causal proteins, the need to assess the potential ability of a novel target to be modulated positively or negatively by treatments, colloquially known as druggability, remains a key challenge in the development of new drugs (99, 100)

doi: 10.1007/bf02009388 83 ZauraEBrandtBWTeixeira De MattosMJBuijsMJCaspersMPRashidMUet al

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10.3109/10717544.2013.846435 Weerakody, R., Fagan, P