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Similarly, Trx1 suppressed NLRP3 inflammasome activation and pro-IL1 production by inhibiting the IRE1 signaling pathway-mediated ER stress, thereby attenuating cellular ROS generation and mitigating the inflammatory response [131]

[Abstract] Virol Sin

doi: 10.3389/fimmu.2024.1356369 Received 15 December 2023 Accepted 26 March 2024 Published 10 April 2024 Volume 15 - 2024 Edited by Shawn Iadonato, Kineta, United States Reviewed by Wenzheng Guo, University of Kentucky, United States Pinglong Xu, Zhejiang University, China Updates Copyright 2024 Schmid, Fischer, Engl, Widder, Kerschbaum-Gruber and Slade