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Moreover, it is known that stress conditions often result in exhaustion of the substrates of the antioxidant enzymes, especially at the initial phase of the introduction of stress factors

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If so, the treatment approach may need to be changed accordingly

Safety data suggest that active folate derivatives are well tolerated and may represent a promising adjunctive strategy in BD management

Glutathione plays a key role in the immune system by promoting T-cell production

Apart from the studies conducted in Germany (Reference Moghaddam, Heller and Sun40,Reference Heller, Sun and Hackler41,Reference Hackler, Heller and Sun42) , some six other studies have assessed Se in serum/plasma (g/l) in COVID-19 patients and found lower Se status in those with COVID than in healthy persons (Reference Du Laing, Petrovic and Lachat43,Reference Fakhrolmobasheri, Mazaheri-Tehrani and Kieliszek44,Reference Younesian, Khodabakhshi and Abdolahi45)