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Newly identified monogenic entities such as DADA2 (deficiency of adenosine deaminase 2) and VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome also exhibit vasculitic features and are associated with a high risk of thrombosis

Chen et al., reported higher AUC (area under the curve) of gefitinib in individuals who were carriers of the CC genotype (AUC 0-t = 6157.34 2049.21 ng.h/mL and AUC 0- = 6624.62 2227.05 ng.h/mL) than in those with CT/TT genotype (AUC 0-t = 5051.26 1575.83 ng.h/mL and AUC 0- = 5361.12 1807.07 ng.h/mL) (unadjusted p G), which is an intronic variant present in intron 3 of the CYP3A5 gene

longa are a blend of three curcuminoids: diferuloylmethane (94%, C 21 H 20 O 6 , curcumin I), demethoxycurcumin (6%, C 20 H 18 O 5 , curcumin II), and bis-demethoxycurcumin (0.3%, C 19 H 16 O 4 , curcumin III) ( 2 groups in the -diketone moiety of these compounds confer anti-inflammatory and antioxidant properties, among other bioactivities, making curcumin a valuable nutraceutical for chemo-preventive and therapeutic applications ( Furthermore, curcumin is soluble in organic solvents such as methanol, ethanol, acetone, and dimethyl sulfoxide (DMSO) but is insoluble in water

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J Exp Bot 66(13):38153829

Gastroenterol Hepatol 2021, 44:112