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First, metabolic regulation occurs through direct modification of metabolic enzymes affecting their activity and stability, as demonstrated in the glycolysis pathway regulation [56]

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[1] [2] Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist

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Mitochondrial ROS production and oxidative mtDNA damage is increased during reoxygenation in the GPX1 knockout mice, in addition to structural abnormalities in cardiac mitochondria and myocytes, suggesting GPX1 may play an important role in protecting cardiac mitochondria from reoxygenation damage in vivo

The peptide is typically administered via subcutaneous injection