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A landmark study published in Science Translational Medicine in 2015 provided molecular evidence for this association

To understand why non-tumor lymphoid cells do not grow within 3D gels, we cultured activated PBLs, LCLs, and lymphoma cells within such gels for 2472 h and then analyzed their cell cycle and viability using flow cytometry

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These functional findings reconciled with the antiangiogenic effects of combination therapy

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