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The buildup of specific lipid species, especially Diacylglycerol (DAGs) and ceramides, causes oxidative damage through ROS generation

Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK inhibition

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This analysis, which encompassed 10 cohort studies with a total of 182,202 middle-aged subjects and approximately 8,500 cases of extrahepatic cancers at different sites over a median follow-up of 5.8 years, revealed that MASLD increases the risk of thyroid cancer by approximately 2.5-fold

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In vivo and in vitro studies have confirmed that GSK-3 activation is involved in NF-B activation, suggesting crosstalk between ER stress and NF-B through IRE1/GSK3 pathway (131, 132)