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BTK activation induces B cells survival, proliferation, and differentiation by the SYK-BTK axis (137), which is an attractive therapeutic target for RA

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Nonetheless, a subset of patients may experience recurrence and metastasis, accompanied by progressive dedifferentiation during the course of treatment

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De Vuyst P, Dumortier P, Schandene L, Estenne M, Verhest A, Yernault JC

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