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No pharmaceutical company has filed an IND application for TB-500 as a therapeutic agent

10.1016/j.neulet.2006.12.044 178 MazzantiG.Di GiacomoS

This function is particularly important under mechanical strain or ischemic conditions, which may arise in tendons due to their relatively low vascularity and transient reductions in blood flow during repetitive loading, leading to hypoxia and increased mitochondrial ROS production (Ostrom et al., 2025