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Acute trials in healthy, physically active men demonstrate that ingestion of 0.9 g/kg fat free mass (FFM) produces greater, but still mild gastrointestinal symptoms, such as nausea, upper gastrointestinal pain, and discomfort, compared with lower doses [87]

3d), consistent with ABHD11 specificity for lipoyl adducts

Among deubiquitinating enzymes, ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) was found to be oxidatively modified in AD brain, and its activity was also found to be reduced (18, 305, 342, 357)

1C,D,F), however, the effect size was less robust than for NMN treatment (Fig

In many areas, BPC-157 is marketed as research chemicals or not for human use, which means no typical labeling, batch testing, or regulation

doi: 10.1093/brain/awad038 47 KimJ