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The activity of Nrf2 is repressed by a redox-sensitive Kelch-like ECH-associated protein (Keap1), which acts as a substrate adaptor protein that interacts with Nrf2 in the cytoplasm, promoting its polyubiquitination by the Cullin 3 (Cul3) E3 ubiquitin ligase (McMahon et al

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[DOI] [PubMed] [Google Scholar] Brand-Miller JC, Liu V, Petocz P, Baxter RC

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