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The analysis revealed pathological collagen fiber proliferation in the model group, which was significantly attenuated in the POPS-treated group (Figures 6J, K)

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An increased kynurenine/tryptophan (Kyn/Trp) ratio correlates with disease The kynurenine pathway is a major route of tryptophan metabolism in humans, in which the enzyme indoleamine 2,3-dioxygenase ( IDO1 ) converts tryptophan to kynurenine via the intermediate N-formyl L-kynurenine, followed by deformylation mediated by arylformamidase [58,59,60], for a schematic illustration, see Fig

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Hanif S, Anila S, Muhammad Z

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Similarly, Gallon et al

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