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Sulfasalazine, a potent inhibitor of the cystine/glutamate transporter, was administered daily from day 14 after IRI, when the formation of TLS was initiated (a preventive model

Pharmacological studies indicate that extracts from these plants exert therapeutic effects against PD through mechanisms such as antioxidant and anti-inflammatory actions, inhibition of -syn aggregation, preservation of dopaminergic neuron survival, and restoration of synaptic function ( in vitro cell experiments and in vivo animal models)

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Thus, the mechanism underlying the anti-inflammatory effect of DFO may be due to a reduction in the number of inflammatory cells (e.g., lymphocytes) (Choi et al., 2004)

Aspartame induced a small but statistically significant increase in DNA strand breaks according to the alkaline comet assay in bone marrow of mice exposed to a single oral dose at 35 mg/kg bw by gavage (Bandyopadhyay et al., 2008)