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[39] These allergic reaction-like symptoms, which typically occur within 3060 minutes of ingesting alcoholic beverages, do not appear to reflect the operation of classical IgE- or T cell-related allergen-induced reactions but rather are due, at least in large part, to the action of acetaldehyde in stimulating tissues to release histamine, the probable evoker of these symptoms

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While our results are consistent with a senolytic effect of GPX4 inhibitors, the effects observed in some of the models, although significant, were modest, and we acknowledge that further investigation is needed to assess a potential translation to the clinic