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This dual alteration attenuates mTOR activity, which in turn inhibits downstream protein synthesis mediated by eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase (p70S6K)

REM sleep is an active stage of sleep occurring about 90 minutes into the sleep cycle, which includes rapid eye movements and brain activity similar to waking levels

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For instance, pharmacological inhibitors of complex I not only deplete CoQ 10 H 2 but also impair ATP production, which activates AMP-activated protein kinase (AMPK) 108

As mentioned above, increased muscle mass is a strong independent predictor of all-cause mortality