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That is accomplished by antioxidant activity, so it is crucial to have ample amounts of antioxidants in the diet for this process

doi: 10.1016/j.cell.2018.07.017 109 ChenZXLiuHQWuZHHeJLZhongHJ

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found that high levels can upregulate the expression of NOX4, NLRP3, and caspase-1 in ECs and showed that high glucose-induced NLRP3 inflammasome activation was dependent on NOX4 and mediates EC tight junction barrier disruption (91)

Transcriptional regulation of PNPLA3 and its impact on susceptibility to nonalcoholic fatty liver Disease (NAFLD) in humans