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The therapeutic era of peptides began in 1921 with the discovery of insulin, a breakthrough that revolutionized diabetes and helped establish biologic therapies in medicine Since then, peptide hormones like oxytocin and human growth hormone (GH) have entered clinical use, and glucagon-like peptide-1 (GLP-1) receptor agonists such as semaglutide are now widely prescribed for obesity and metabolic diseaseconditions increasingly recognized for their effect on orthopaedic outcomes

TB-500: the mobility and repair peptide TB-500 is a synthetic fragment of thymosin beta-4, a naturally occurring 43-amino-acid peptide involved in cell migration, blood vessel formation, and tissue repair