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Brain cells are particularly susceptible, owing to their low antioxidant defences and high oxidative metabolic activity

To further clarify the role of theaflavins in ferroptosis induced by iron overload, Ferric ammonium citrate (FAC) at a concentration of 1000 M was added to the culture medium of primary hepatocytes, followed by the addition of 50 M and 100 M theaflavins

doi: 10.1016/j.joca.2015.03.031 132 MooneyRASampsonERLereaJRosierRNZuscikMJ

Peroxidases of trypanosomatids

Vascular cell 6 , 18, (2014)

Although preclinical evidence suggests that GLP-1RAs can cross the blood-brain barrier (BBB), the efficacy of CNS delivery and the precise therapeutic dosage necessary to achieve neuroprotective concentrations in people are unclear