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George Barth Geller Distinguished Professor of Medicine Professor of Medicine Chair, Department of Medicine Member of the Duke Cancer Institute Member of Duke Molecular Physiology Institute Chair, Department of Medicine Member of the Duke Cancer Institute Member of Duke Molecular Physiology Institute

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3.6 PheWas To thoroughly assess whether the identified potential drug target gene TOR1B might exert beneficial or detrimental effects on other traits, and to explore potential pleiotropy not captured by the MR-Egger intercept test, we utilized 17,361 binary phenotypes and 1,419 quantitative phenotypes from the AstraZeneca PheWAS portal