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Dysesthesia (altered skin sensation) as a GLP-1-class effect retatrutide TRIUMPH-1 treatment-emergent rate 5.1 / 12.3 / 12.5% at 4 / 9 / 12 mg vs 0.9% placebo

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Retatrutide has been studied at weekly subcutaneous doses of 0.5 mg, 1 mg, 2 mg, 4 mg, 8 mg, and 12 mg in Phase 2 research

The FDA also notes that 28 days is the assumed opened-vial period for this kind of container unless the label specifies something else

There are two hypotheses