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After treatment, the medium was removed, and 20 L/well of fresh medium containing luminogenic CYP substrate was added, followed by a 1-hour incubation at 37 C

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For the kidney, degeneration of glomerular structure and dilatation of Bowmans space, degeneration of proximal and distal tubule, vascular congestion and inflammatory cell infiltration were taken into consideration

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Methods: We assembled a retrospective cohort of adults with PreDM in a large, urban PC practice