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These changes are attributed to reduced output of clock gene expression in the suprachiasmatic nucleus (SCN) (Musiek and Holtzman, 2016), neuronal loss, and imbalances in neurohormonal and neurotransmitter systems arising from age-mediated changes in the central nervous system (Zhong et al., 2019)

Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis

Fei Z, Fan F, Liao J, Wan M, Bai W, Wang W, He M, Li Y

[DOI] [PubMed] [Google Scholar] 12.Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB

Hepatocellular carcinoma in cirrhosis: incidence and risk factors

10.1007/s00401-018-1922-z 45 WuJ.AkkuratovE