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Furthermore, no significant damage was observed in H&E staining images of major organs (heart, spleen, lung, and kidney), confirming their excellent biosafety (Supplementary Fig

544, Harbin, China

Senescent cells are also characterized by reduced mitophagy, leading to the accumulation of dysfunctional mitochondria and a noticeable increase in mitochondrial presence within the cell, which may serve as another indicator of cellular senescence [25]

Productivity and functionality was increased by adjusting the various PURE components (Li et al., 2014) and by supplementing additional factors to the system (Maddalena et al., 2016

They either promote or inhibit the spliceosome assembly at specific splice sites by binding to regulatory sequences within the pre-mRNA 34