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Dysfunction of intestinal epithelial cell polarity and function can trigger potent inflammatory responses within the gut, and related to this, mice deficient in Ap1m2, a master regulator of intestinal epithelial cell polarization, demonstrate chronic colitis

doi: 10.1016/j.tplants.2018.06.004 64 Rodriguez-PeaR.MounadiK

Bailey EE, Pfeifer HH, Thiele EA

A program without a target cannot be optimized through medicinal chemistry, cannot generate target-engagement biomarkers and cannot be de-risked for off-target liabilities

Zooming out : Wells Fargo's move fits a broader industry pattern as lenders adapt to shifting market conditions

M., Dudka V