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As of 2022, it is included in WADAs prohibited substances list

High-efficiency anti-stress effect: alleviate heat stress and other stresses such as performance decline caused by vaccination

Mast cell corticotropin-releasing factor subtype 2 suppresses mast cell degranulation and limits the severity of anaphylaxis and stress-induced intestinal permeability

445 Additionally, intracellular HSP90, which is involved in the activation of both innate and adaptive immune responses, has been implicated in autoimmune processes