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10.1016/j.fbio.2024.104626 11 GongH.FuH.ZhangJ.ZhangQ.WangY.WangD.et al (2024)

J Shoulder Elbow Surg

Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity

Mycotoxin-producing molds grow on food like cereals (corn, sorghum, wheat, and rice), oilseeds (soybean, peanut, sunflower, and cotton seeds), spices (chili peppers, black pepper, coriander, turmeric, and ginger), and tree nuts (pistachio, almond, walnut, coconut and Brazil nut)

Area per lipid and membrane width together indicate accessibility to oxidants, with greater area per lipid and decreased membrane width having higher accessibility due to the more exposed lipid tails

from tryptophan, tryptophan hydroxylase produces 5-hydroxytryptophan, then AADC produces serotonin, which N-acetyltransferase and HIOMT convert to melatonin (in darkness)