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Neural Tube Defects Deficiency in early pregnancy increases the risk of brain and spinal cord malformations, especially when combined with low folate [*]

Some individuals experience stinging, pain, or tingling instead of itching. Other symptoms of vitamin B12 deficiency Other symptoms of the condition are listed by Bupa as: Feeling very tired Breathlessness even after a little exercise Heart palpitations Headaches A reduced appetite A sore mouth The health organisation adds: If you have vitamin B12-deficiency anaemia, you may also look pale or jaundiced (have a yellowy tinge to your skin and the whites of your eyes)

Thiamine and pyridoxine deficiency: new insights into clinical disorders

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while the acute repletion might be IV/IM for a period, they may transition to high-dose oral vitamins thereafter