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Its use for wellness, detoxification, or skin brightening is considered "off-label." Off-label use is a common medical practice where a doctor prescribes a medication for a purpose different from its original FDA approval, based on professional judgment and scientific evidence

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Reconstituting with sterile water instead of bacteriostatic water

If a physician determines GH axis intervention is clinically appropriate, those approved options represent a much higher evidence standard

[9] The compound gained regulatory approval in the United States in 1997 for diagnostic use, but its clinical adoption remained limited compared with other endocrine testing methods