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It has been demonstrated that membrane cholesterol changes the features of the cell membrane, e.g

2 and 3), suggesting the essential role of the Ang II/AT 1 receptor system in DPN development

While this study provides significant insights, it has several limitations: (1) Restricted age range: The study included only healthy adults aged 20 to 79 years, excluding specific groups such as pregnant women, infants, and adolescents

This method comprises administering to the subject an effective amount of a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound having the structure of formula (I): R 1 and R 2 , are independently selected from the group consisting of no atom, H, D, O, halo, C 1-6 alkyl, C 1-6 alkyl-aryl, C 1-6 alkyl-heteroaryl, C 1-6 alkenyl, C 1-6 alkenyl-aryl, and C 1-6 alkenyl-heteroaryl, wherein the C 1-6 alkyl, C 1-6 alkyl-aryl, C 1-6 alkyl-heteroaryl, C 1-6 alkenyl, C 1-6 alkenyl-aryl, and C 1-6 alkenyl-heteroaryl may be optionally substituted with an atom or a group selected from the group consisting of halo, deuterium, C 1-4 alkyl, CF 3 , and combinations thereof

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