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In fact, circulating adducts between hemoglobin and NAPQI have been detected, indicating some NAPQI even escapes hepatocytes, diffuses into RBCs, and combines with hemoglobin during its short existence

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Recently, it is also considered to be one of the factors leading to the development of neurodegenerative and neuroinflammatory diseases of the central nervous system, e.g., multiple sclerosis, Alzheimers disease, or Parkinsons disease [25,29,30]

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Mammals harbor 19 different wnt and 10 fzd genes

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