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Consequently, in response to oxidative stress, hepatocytes stimulate necrotic and apoptotic pathways, leading to impaired liver function, worsened paracrine inflammation, and fibrogenesis [36]

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Thus the best-known "function" of B 12 (that which is involved with DNA synthesis, cell division, and anemia) is a facultative function that is mediated by B 12 -conservation of an active form of folate which is needed for efficient DNA production

In senescent cells, the transcription factor FOXO4 binds to p53 (the tumor suppressor "guardian of the genome"), sequestering p53 away from mitochondria where it would trigger apoptosis