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Further studies have better characterized the cytokine and chemokine profiles in patients with long COVID that had associated proinflammatory shifts in gut microbial composition [80]

These effects are likely mediated through mechanisms similar to selective serotonin reuptake inhibitors, enhancing serotonin activity (Shahmoradi et al., 2023)

Therefore, modification of SAE with natural macromolecules has emerged as a promising approach for improving bio-applicability of inorganic nanomaterials 15

Hence, these data imply that loss of PDI function contributes to pathophysiology in ALS and that PDI controls the cellular redox environment in the development of neurodegeneration