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To explore this possibility, we characterized human fecal polymicrobial metabolism under ex vivo anaerobic conditions using distinct heavy isotopelabeled substrates i.e., synthetic d 3 -l-carnitine and d 9 -BB, allowing us to monitor d 3 -TMA (from carnitine) and d 9 -TMA (from BB) at the same time from both omnivores ( n = 10) and vegans/vegetarians ( n = 10) (Figure 3, D and E)

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Meta-analytical evidence has demonstrated limited benefit over placebo in reducing OA pain, particularly in knee and hip OA, and its use is increasingly de-emphasized in clinical guidelines ( TABLE 2 Pharmacological therapies for osteoarthritis: clinical use, evidence, and limitations

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73 , 13451349 (1991) McCloskey, J.A., Nishimura, S.: Modified nucleosides in transfer-RNA