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Additionally, alanine mutations of E124 3.33 and R283 6.55 also lead to the significantly diminished basal activity of the ghrelin receptor, indicating a potential role of the salt bridge formed by these residues in modulating the receptors basal activity (Supplementary Fig

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The proinflammatory ability of some microbial peptide structures of SLE-enriched species was also confirmed by functional validation assays (176)

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