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Supplementation with gamma-glutamylcysteine has shown to increase cellular glutathione levels above homeostasis [14] and therefore proves to have potential value as a preventative therapy for osteoporosis by reducing oxidative stress and optimizing Vitamin D and calcium absorption

In vitro , HA@M@PB@SINNPs inhibited fibroblast-like synoviocyte proliferation by scavenging ROS and suppressing the secretion of pro-inflammatory cytokines

Other studies have discovered that hypoxia promotes the expression of ectonucleotidases CD39 and CD73, which can transfer ATP to adenosine, are promoted on various cells in the TME (122, 123)

Hydrophobic forces were observed between the side chains of the peptide and the methyl groups of thymine

DECLARATIONS Acknowledgements We are grateful for the valuable discussions and computational resources provided by the Beijing Computational Science Research Center (CSRC), and acknowledge the support from the Talent Hub for AI+ New Materials Basic Research

As we further understand pathophysiological nuances, pharmacological approaches may provide improved symptom control