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doi: 10.1016/j.canlet.2023.216494 62 GaoBWangSLiJHanNGeHZhangGet al

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Immune response becomes less efficient

After exiting the cell cycle, cells enter into a hypersecretory state, secreting inflammatory cytokines, chemokines, and growth factors, which is termed senescenceassociated secretory phenotype (SASP) [135]