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Also, it is implicated in the down-regulation of the expression of MIF, the number of macrophages, and the amount of macrophage-related cytokines, including MCRP1 MIP-3 [82], inhibition of IL-33 expression and subsequent NF-B activation [83], blockage of the TLR4/NF-B-p65/IL-6 signaling pathway [84], regulation of the autophagic flux [85], modulation of gut microbiota and SCFAs [86], amelioration of inflammation, oxidative stress and apoptosis in intestinal cells [87,88], and control of sphingolipid metabolism and sphingolipid signaling pathway [89]

Treatment with both TLYYL and TLYYH significantly restored GSH-Px and SOD activities, with the TLYYH group also demonstrating a significant reduction in MDA levels

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Since endothelial cells contain more proteoglycans with negative charges, positively charged nanoparticles are more permeable across the BBB

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