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MT-encoding genes are expressed in several tissues and organs, including both brown and white adipose tissues (WAT)

We also recognize that for many families and individuals with autism, the effect on function and quality of life is profoundly impairing and life-altering, affecting not only the lives of the individual but those who care for them

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Participants were categorised as cognitively impaired/unimpaired via longitudinal clinical consensus

Studies measuring CSF levels of lysosomal hydrolases (involved in the -Syn degradation) found decreased (Balducci et al., 2013b), or increased (Parnetti et al., 2014a) -hexosaminidase, increased cathepsin E (van Dijk et al., 2013b), decreased -mannosidase (Balducci et al., 2011