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For example, one study developed a prognostic model based on ferroptosis-related genes using RNA-seq data from NSCLC patients, revealing that patients in the high-risk group had significantly lower overall survival compared to those in the low-risk group ( These findings indicate that ferroptosis-related genes not only play a pivotal role in the initiation and progression of lung cancer but also have potential clinical applications, providing a foundation for the development of personalized treatment strategies

Mandell DS, Thompson WW, Weintraub ES, Destefano F, Blank MB

Polimanti R, Carboni C, Baesso I, Piacentini S, Iorio A, De Stefano GF et al (2013) Genetic variability of glutathione S-transferase enzymes in human populations: functional inter-ethnic differences in detoxification systems

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Drouin J, Trifiro MA, Plante RK, Nemer M, Eriksson P, Wrange O