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Presynaptic cytoplasmic Ca 2+ can be depleted by several complementary mechanisms, including sarcoendoplasmic reticulum Ca 2+ -ATPase (SERCA) to the endoplasmic reticulum (ER), plasma membrane Ca 2+ -ATPase to the extracellular space, and MCU to the mitochondrial matrix [51,52,53]

I 2 = 88.6%, p 30 kg/m 2 ), and diabetic patients

Each item is scored on a scale from 1 (within normal limits) to 4 (severely abnormal), yielding a total score range of 1560