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doi: 10.1002/cbdv.202402248 105 ZhaoJ-WZhaoW-YZhaoMYuL

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Which intracellular signalling pathways does IGF-1 LR3 activate via IGF-1R

Thus, overactive mTORC1 inhibits mitophagy, leading to the accumulation of dysfunctional mitochondria, which contributes to increased ROS production and reduced cellular energy efficiency