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A: The duration of effects can vary

But the current state of evidence does not support the confidence that the public places in it

(2) the APL Revolution (1970s-2000), marked by the identification of the promyelocytic leukemia protein (PML)-retinoic acid receptor alpha (RAR) fusion protein as a specific molecular target, elucidation of the small ubiquitin-related modifier (SUMO)ylation-dependent degradation mechanism, and subsequent Food and Drug Administration (FDA) approval, establishing a precision paradigm