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Subunits of CRL4 DCAF16 were identified only for dHTC2, while FBXO3, a substrate receptor of the SKP1-CUL1-F box (SCF) complex, was identified only for dHTC3 (Fig

The expression of Snail1 is directly modulated by Notch signaling, and the Notch/Snail pathway plays a critical role in the pathogenesis of renal interstitial fibrosis in DN (Yang et al., 2017)

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When the plasma iron level meets the systemic iron demand, the liver will increase the secretion of hepcidin into the blood, reducing the plasma iron level and maintaining iron homeostasis in the body (39)

The cells were transfected with siRNAs using Lipofectamine RNAi MAX Reagent (Invitrogen, CA, United States) according to the manufacturers instructions

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