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NMN supplementation in mice also improved mitochondrial morphology through DRP1, and reduced ROS through antioxidant response expression 113

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Although there was no involvement of circular RNA in our study, DCM was associated with left ventricular diastolic dysfunction (LVDV: SMD: 4.93, 95%CI 3.35, 6.50, p = 0.00001) followed by systolic dysfunction (LVSV: SMD: -1.38, 95%CI -1.38, 4.13, p = 0.33) between the DCM and the healthy control groups which confirm the establishment of DCM in mouse models which gradually progress into DCM in both mice and the humans

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PMID: 37356476

Furthermore, modulation of the thymus index and an amelioration of splenomegaly were observed