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[27] Hypertrichosis (elongation, thickening, and enhancement of fine body hair), without evidence of virilism or endocrine abnormalities, is an embarrassing adverse effect that often occurs with oral minoxidil

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Prevent neural tube defects Low vitamin B12 levels in mothers have been associated with neural tube defects in infants

TM6 undergoes the characteristic outward rotation that opens the G protein-binding cavity, TM5 repositions to form the lateral wall of this cavity, and the intracellular ends of TM3 and TM7 reorganize to complete the G protein docking surface