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Patients say things like, My eyes feel heavy, or I could fall asleep in the afternoon even if I want to stay productive. Depression-related fatigue often feels heavier and broader

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It suggests that dietary interventions to reduce Neu5Gc (e.g., limiting red meat) might theoretically enhance Siglec-8's protective signaling, whereas Neu5Gc-rich diets might worsen eosinophil-driven inflammation by undermining this checkpoint (201203)

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