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Nausea, vomiting, and diarrhea beyond normal adaptation responses can occur with excessive doses

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due to their biological characteristics, these bacteria can survive and reproduce in the host with a weakened immune system and even break through the intestinal barrier to cause bacteremia

Knee osteoarthritis has doubled in prevalence since the mid-20th century

This may also lead to gall bladder disease and increase the risk of gall stone production

Of solved structures, all GS enzymes have a composite active site with residues contributed from two adjacent protomers